Fluticasone Nasal Spray Versus Oral Fexofenadine in Management of Allergic Rhinitis

Authors

Muhammad Faran Sarwar District Head Quarters Hospital, Toba Tek Singh
Umera Iftikhar Mohi ud Din Teaching Hospital Mirpur AJK
Sassi Kanwal Bahria University of Health Sciences, Karachi
Mehwish Mansoor Bahria University of Health Sciences, Karachi
Fahad Usman Sialkot medical college
Sadia Rehman Assistant Professor Bahria Medical University Karachi

DOI:

https://doi.org/10.51273/esc25.251321110

Abstract

Abstract
Objective: To evaluate the effectiveness of fluticasone nasal spray compared to oral fexofenadine in the
treatment of allergic rhinitis.
Material and Methods: This cohort study was conducted at the Department of ENT, King Edward Medical
University, Lahore from 17th April 2023 to 7th October 2023. A total of 120 patients aged 18-60 years with
symptomatic allergic rhinitis were included. Patients were randomly assigned to two groups: Group X (n=60)
received intranasal corticosteroid (Ticovate® nasal spray, fluticasone propionate 50mcg) one spray in both
nostrils twice daily, and Group Y (n=60) received oral fexofenadine 120 mg once daily. The total nasal
symptom score (TNSS) was assessed after 4 weeks of treatment during the follow-up visit. For statistical
analysis, data were analyzed using SPSS version 21.0. Descriptive statistics were used to summarize
demographic data. The TNSS was compared between the two groups using an independent sample t-test to
assess the differences in mean scores after treatment. A p-value of less than 0.05 was considered statistically
significant.
Results: Out of 120 patients, 79 (65%) were males and 41 (35%) were females, with a mean age of 37 years.
The study showed a significant difference in treatment outcomes, with Group X demonstrating a greater
reduction in TNSS compared to Group Y. Specifically, 90% (n=27) of patients in Group X experienced a
substantial improvement, while only 16.67% (n=5) in Group Y reported similar results (p=0.000).
Conclusion: Fluticasone intranasal spray is significantly more effective than oral fexofenadine in managing
allergic rhinitis, as demonstrated by a greater reduction in the mean total nasal symptom score.
Keywords: Allergic Rhinitis, Fluticasone Nasal Spray, Fexofenadine, Total Nasal Symptom Score,
Intranasal Corticosteroid.
How to cite: Sarwar MF, Iftikhar U, Kanwal S, Mansoor M, Usman F, Rehman S. Fluticasone Nasal Spray Versus Oral
Fexofenadine In Management Of Allergic Rhinitis. Esculapio - JSIMS 2025;21(01): 53-59
DOI: https://doi.org/10.51273/esc25.251321110

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Published

2025-05-12

How to Cite

Muhammad Faran Sarwar, Umera Iftikhar, Sassi Kanwal, Mehwish Mansoor, Fahad Usman, Sadia Rehman. Fluticasone Nasal Spray Versus Oral Fexofenadine in Management of Allergic Rhinitis. Esculapio - JSIMS [Internet]. 2025 May 12 [cited 2025 May 13];21(1):53-9. Available from: https://esculapio.pk/journal/index.php/journal-files/article/view/1215