Comparison of the Outcome of Administration of Tranexamic Acid During Percutaneous Nephrolithotomy at Tertiary Care Hospital

Authors

Farhan Khan Assistant Professor of Urology, Bilawal medical college for Boys, LUMHS Jamshoro, Pakistan
Muhammad Hayat Kakar Baluchistan institute of nephro Urology Quetta
Muhammad Adnan Sarwar Bahawal Victoria Hospital Bahawalpur
Muhammad Mashkoor Aslam Shahida Islam Teaching hospital, Lodhran
Haider Ali Qureshi Liaquat University of Medical and health Sciences Jamshoro
Hafiz Bilal Murtaza University of Agriculture Faisalabad

DOI:

Keywords:

Percutaneous nephrolithotomy, Tranexamic acid, Surgical bleeding, Blood loss, Transfusion requirements, Urological surgery

Abstract

Abstract
Objective: To evaluates the safety and effectiveness of TXA in minimizing blood loss and transfusion needs
during PCNL.
Material and Methods: A Quasi-Experimental Design was conducted at Liaquat University of Medical and
Health Sciences, Jamshoro, from October 1, 2023, to March 31, 2024, including 96 PCNL patients.
Participants were assigned to either the TXA group (1g intravenous TXA, 20 minutes preoperatively) or the
placebo group (10 cc normal saline), each with 48 patients. Blood loss was assessed via perioperative
hemoglobin levels and irrigation fluid volume. Transfusion needs, operative time, and patient demographics
were analyzed using SPSS version 16, with a p-value ≤ 0.05 considered significant.
Results: TXA significantly reduced blood loss (75.38 ± 59.29 mL vs. 113.57 ± 82.36 mL; p=0.001) and
transfusion rates (16.7% vs. 20.8%; p=0.01). Operative time and obesity influenced transfusion needs, but
TXA consistently reduced blood loss across subgroups. No significant thromboembolic complications were
observed.
Conclusion: TXA effectively reduces blood loss and transfusion requirements during PCNL without
increasing adverse events, making it a valuable adjunct in high-risk patients. Further studies are needed to
standardize dosing and assess long-term outcomes.
Keywords: Percutaneous nephrolithotomy, Tranexamic acid, Surgical bleeding, Blood loss, Transfusion
requirements, Urological surgery
How to cite: Khan F, Kakar MH, Sarwar MA, Aslam MM, Qureshi HA, Murtaza HB. Comparison Of The Outcome Of
Administration Of Tranexamic Acid During Percutaneous Nephrolithotomy At Tertiary Care Hospital. Esculapio -
JSIMS 2025;21(01): 3-8
DOI: https://doi.org/10.51273/esc25.2513211

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Published

2025-05-12

How to Cite

Farhan Khan, Muhammad Hayat Kakar, Muhammad Adnan Sarwar, Muhammad Mashkoor Aslam, Haider Ali Qureshi, Hafiz Bilal Murtaza. Comparison of the Outcome of Administration of Tranexamic Acid During Percutaneous Nephrolithotomy at Tertiary Care Hospital. Esculapio - JSIMS [Internet]. 2025 May 12 [cited 2025 May 13];21(1):3-8. Available from: https://esculapio.pk/journal/index.php/journal-files/article/view/1210