Exploring the Rate of Mortality in Critically Ill Patients with Acute Kidney Injury: A Comprehensive Analysis Stratified by Rifle Classification
DOI:
https://doi.org/10.51273/esc25.251321113Keywords:
Acute kidney injury, Critical illness, Hospital, Intensive care units, MortalityAbstract
Abstract
Objective: To determine the rate of mortality among critically ill patients with acute kidney injury using the
RIFLE classification.
Material and Methods: This comprehensive analysis of cross-sectional study was done in Intensive Care
Unit between April 2022 and April 2023 in a tertiary care hospital, Akbar Niazi Teaching Hospital, Islamabad
Pakistan. Total 350 patients were admitted in the ICU of the hospital, ages 18 years and above, presented with
critical illness. The RIFLE classification was employed to assess patient mortality, revealing that individuals
in the R, I, and F classes had higher mortality rates than those with normal kidney function. Regression model
and odd ratio analysis was conducted to measure the association between the maximum RIFLE stage and
mortality.
Results: The patients mean age was 48.58±17.12 years. Among 350 patients, 65.1% (n=228) developed AKI,
whereas 34.9% (n=122) had normal kidney functions. The mean urine output value was 40.04±48.09 ml/hr,
with 43% patients was anuric and creatinine was 4.37±3.52 mg/dl. Patients in the RIFLE classes R, I, and F
exhibited hospital mortality rate was 2.2%, 4.8%, and 11.4%, respectively. The odd ratio for in-hospital
mortality associated with AKI and RIFLE classes R, I, and F was 1.9 (1.56-2.40, p = 0.0001), 1.1 (0.80-1.40, p
= 0.231), 1.5 (1.1-2.00, p ≤ 0.001), and 4.0 (3.50-4.50, p = 0.0001), respectively.
Conclusion: Hospital mortality is elevated in cases of AKI as per the RIFLE classification. Notably, patients
falling into RIFLE class R face a heightened risk of advancing to either stage I or F.
Keywords: Acute kidney injury; Critical illness; Hospital; Intensive care units; Mortality.
How to cite: Karmani JK, Mumtaz A, Khan Z, Areej A, Shah SAA, Yasmin R. Exploring The Rate of Mortality in
Critically ill Patients with Acute Kidney Injury: A Comprehensive Analysis Stratified by Rifle Classification.
Esculapio - JSIMS 2025;21(01): 70-74
DOI: https://doi.org/10.51273/esc25.251321113
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