Diagnostic Accuracy of Urinary Kidney Injury Molecule-1 in Early Diagnosis of Acute Kidney Injury in Cardiopulmonary Bypass Patients
DOI:
https://doi.org/10.51273/esc25.2513215Keywords:
Serum Creatinine, Urinary KIM-1, Acute Kidney Injury, Cardiopulmonary BypassAbstract
Abstract
Objective: To assess diagnostic accuracy of KIM-1 as compared to serum creatinine in patients undergoing
cardiopulmonary bypass for diagnosis of acute kidney injury.
Material and Methods: This is a comparative cross-sectional study and was conducted in the Biochemistry
& Chemical Pathology department of Shaikh Zayed Hospital Lahore over the course of one year. The study
received approval from the organization's ethical committee (Letter No. SZMC/IRB/Internal/0059/2021). A
total of 190 patients who met the inclusion criteria were included in the study. Blood samples for serum
creatinine and urine samples for KIM-1 were collected pre-operatively, 3hrs and 24hrs after surgery.
Quantitative analysis of serum creatinine and urinary KIM-1 were done. Reports were evaluated and levels
were recorded. Data was analyzed by SPSS 25.0.
Results: Out of 190 patients, 26(13.7%) developed AKI after cardiopulmonary bypass diagnosed by high
serum creatinine. Serum creatinine started to rise in the patients after 24hrs of surgery whereas urinary KIM-1
showed increased in level 3hrs after surgery. Sensitivity of KIM-1 at 3hrs in patients who developed AKI was
found to be 92.3% and specificity was 87.2% with diagnostic accuracy of 87.9%.
Conclusion: From the findings, it can be concluded that urinary KIM-1 may be used as an early diagnostic
marker of AKI, since it showed an increase within 3hrs post-surgery while serum creatinine level remained
normal during that time and started to rise after 24hours.
Keywords: Serum Creatinine, Urinary KIM-1, Acute Kidney Injury, Cardiopulmonary Bypass
How to cite: Jamil A, Hameed S, Khan M, Naseem T. Diagnostic Accuracy of Urinary Kidney Injury Molecule-1 in
Early Diagnosis of Acute Kidney Injury in Cardiopulmonary Bypass Patients. Esculapio - JSIMS 2025;21(01): 26-30
DOI: https://doi.org/10.51273/esc25.2513215
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