Role of Platelet Large Cell Ratio (P-LCR) for Diagnosis of Immune Thrombocytopenia (ITP)

Abstract

Objective: To determine the diagnostic accuracy of platelet large cell ratio (P-LCR) in diagnosis of immune
thrombocytopenia taking bone marrow examination as gold standard.
Material and Methods: A total number of 194 patients of confirmed hematological patients with platelet
counts below 50 × 109/L were included from Department of hematology, AIMC/Jinnah Hospital Lahore
from 01-Oct-2020 to 30-April-2021. In all patients, venous blood samples were taken and CBC along with P-
LCR analysis was done. Final values of P-LCR were noted. Patients having P-LCR ≥33.15% was labelled as
having ITP. After that patients bone marrow samples were taken for confirmation of bone marrow suppression.
Results: Mean age of patients was 40.39±8.58 years. Mean P-LCR was 32.58±4.11%. There were 126 (64.95%)
male and 68 (35.05%) female patients. ITP on P-LCR was found in 84 (43.30%) patients and ITP on bone marrow
was found in 100 (51.55%) patients. P-LCR was 85.10% sensitive, 72.70% specific, had 70.00% PPV and
83.30% NPV for diagnosis of ITP.
Conclusion: P-LCR at cut off - ≥33.15% found to be highly sensitive for diagnosis of ITP in patients with
thrombocytopenia.
Keywords: Platelet large cell ratio (P-LCR), immune thrombocytopenia, bone marrow.