BMI-Driven Variations in Testosterone, Luteinizing Hormone, Follicle-Stimulating Hormone and Sex Hormone-Binding Globulin in Males

Abstract

Objective: To explore the association of luteinizing hormone (LH), follicle-stimulating hormone (FSH),
total (TT), free (FT), and bioavailable testosterone (BAT), and sex hormone-binding globulin (SHBG) in
relation to body mass index (BMI), in middle aged males recognizing its pivotal role in modulating
homeostasis.
Material and Methods: Ninety-eight participants, aged between 48 and 56 years, were categorized into
three distinct groups based on their BMI: those with a BMI less than 25 (normal), BMI ranging from 25 to 30
(overweight), and BMI exceeding 30 (obese). Rigorous analysis of serum samples enabled the quantification
of luteinizing hormone, follicle-stimulating hormone, total testosterone, free testosterone, bioavailable
testosterone, and sex hormone-binding globulin, with standard procedures employed for body weight and
height measurement.
Results: Statistical comparisons using a one-way analysis of variance (ANOVA) discerned significant
variations across these BMI groups (p-value = 0.001). It revealed significant differences in luteinizing hormone,
follicle-stimulating hormone, total testosterone, and sex hormone-binding globulin concerning BMI across
the three delineated groups. Further reinforcing a negative correlation between testosterone and BMI, a p-
value of 0.005 underscores the impact of BMI on testosterone dynamics.
Conclusions: This study highlights a noticeable decline in luteinizing hormone, follicle-stimulating hormone,
total testosterone, and sex hormone-binding globulin with increasing BMI.
Keywords: Follicle stimulating hormone, luteinizing hormone, free testosterone, bioavailable testosterone,
sex hormone binding globulin.