Comparison of Retinol Binding Protein 4 (RBP 4) Levels in Pregnant Females with and without Gestational Diabetes Mellitus (GDM)

Abstract

Objective: To compare the levels of RBP4 in pregnant females with and without GDM.
Materials and Methods: It was a cross sectional study carried out in Pathology Department KEMU/Mayo
Hospital and Lady Aitchison Hospital, Lahore after approval by Institutional Review Board. After informed
consent, total 64 pregnant females at 24-28 weeks of gestation undergoing OGTT; 32 in group A with GDM
and 32 in group B without GDM were enrolled. Under aseptic conditions, 3ml blood was drawn for RBP-4 to
be measured by ELISA.
Results: The means ± SD age of females was 25.5±4.3 and 24.4±4.4 years in group A and B respectively. The
age, gestational age, parity, previous history of GDM was not significantly different in 2 groups. The median
(IQR) values of RBP4 were 37.3 and 33.2ng/dl in group A and B respectively and were significantly different
(p =0.021).
Conclusion: Serum RBP4 concentrations are high in females with GDM as compared to those without GDM.