Evaluation of the Anti-Tubercular Role of Nimbolide in Animal Model of Tuberculous Arthritis

Abstract

Objective: To evaluate the effect of Nimbolide on tuberculous arthritis in mice.
Material and Method: 24 BALB/c mice were divided by simple random sampling into three groups with 8
animals in each group: normal control, diseased control, and treatment group. Tuberculous arthritis was
induced by injecting 10mg of Mycobacterial tuberculosis H37Rv strain in 1 ml of normal saline into the tail
vein of diseased control and treatment groups. Nimbolide was administered to the treatment group at the dose
of 0.2 mg/kg for 4 weeks from the 5th to the 9th week. Mice were sacrificed under ether anesthesia after 9 weeks.
Results: Nimbolide increased body weight in mice affected by tuberculous arthritis (p < 0.001). Nimbolide
improved the histopathological changes associated with tuberculous arthritis (p < 0.001).
Conclusion: Nimbolide has shown anti-tubercular arthritic activity in mice model of tuberculous arthritis.
Nimbolide can be a possible agent for the treatment of tuberculosis and tuberculous arthritis.