A Comprehensive Assessment of Oxidative Stress from Hematological Parameters in Alzheimer's Patients

Abstract

Objective: To evaluate the relationship between oxidative stress and hematological parameters in patients with Alzheimer's disease.
Material and Methods: This was a cross-sectional study conducted at Liaquat University Hospital from May to July 2022 aimed at assessing Alzheimer's disease (MCI-AD) that causes mild cognitive impairment and also using NIA-AA diagnostic criteria in this study. The study included 300 participants, divided into case and control groups based on cognitive function and neuroimaging. Exclusions were made for individuals with any other additional brain pathology or mental illness that falsifies the study results. Peripheral blood samples were taken under standardized conditions for flow cytometry analysis and also for measuring reactive oxygen species (ROS) and various oxidative stress markers. Flow cytometry data was examined using FCS Express software.
Results: The correlation between oxidative stress and Alzheimer's disease is significant (P = 0.001), with odds ratios ranging from 1.8 to 2.2, sensitivity and specificity values of 0.50 and 0.6, and a robust likelihood ratio of 1.4.
Conclusion: This study underscores the potential relationship between Alzheimer's disease and oxidative stress.
Keywords: Alzheimer's disease, Antioxidants, Free radicals, Neurodegenerative disease, Oxidative stress