Influence of Serum Uric Acid on Mean Arterial Pressure in Females in Local Population

Abstract

Objective: To find out the relationship and effect of hyperuricemia on mean arterial pressure in local population.
Material and Methods: The Study design was Cross sectional and the setting was in Lady Aitchison hospital
Lahore. Duration of this this was March 2017- August 2017. Written informed consent was taken prior to
data collection. Detailed history was asked. Mean arterial pressure was calculated by measuring systolic and
diastolic blood pressures and putting them in the formula: MAP = diastolic pressure + 1/3 (pulse pressure).
Uric acid was measured by uricase method after taking 1 ml venous blood under aseptic measures.
Result: A total of 60 patients with increased serum uric acid levels, with Mean Arterial Pressure ranging
between 83.33 and 126.67 were considered. We use simple linear regression model and see the effect of Uric
Acid on Mean Arterial Pressure. The model shows that for 1 mg/dl increase in Uric Acid, Mean Arterial Pressure
increases by 14.89 at 5% level of significance. 72.74% of the variation in the Mean Arterial Pressure can be
defined using the Uric Acid. Conclusion: Positive relationship has been seen between hyperuricemia and
mean arterial pressure.