Histological Pattern of Oral Squamous Cell Carcinoma with Respect to Age, gender and Site in Pakistan

Abstract

Objective: To assess histological pattern of “oral squamous cell carcinoma (OSCC)” with respect to age,
gender and site in Pakistan.
Material and Methods: This study was Observational descriptive study. “CMH Medical College, Lahore”
from 1st July to 30th December 2023. A total of 150 patients with suspicious chronic oral ulcer were included
in the study. Age, gender, gross appearance and site of ulcer were documented. Biopsy was obtained from the
ulcer to make diagnosis of OSCC and determine its histological type. Data was analyzed using SPSS 22:00.
Results: Mean age of patients with OSCC was 53.07 ± 16.98 years. There were 103 (68.67%) male patients
while 47 (31.33%) patients were females. Mean duration of ulcer was 9.56 ± 2.18 weeks. 106 (70.67%) had
ulcerative lesion, 29 (19.33%) had exophytic lesion and 15 (10.00%) had verrucous lesion. Most common
histological type of OSCC found was “spindle cell carcinoma” in 76 (50.67%) patients. There was no
statistical difference in distribution of histological pattern of OSCC by age group (p = 0.413), gender (p =
0.932) and site of lesion (p = 0.386).
Conclusion: Most common histological type of OSCC was “spindle cell carcinoma” with buccal mucosa
being most common site.
Keywords: Histological type of neoplasm, Oral ulcer, Squamous cell carcinoma.