An Association between Oxidative Stress, and Risk of Development of Cardiovascular Disease in Diabetic Patients

Abstract

Objective: A cross sectional study was carried out to find the association between oxidative stress, and risk of
the development of cardiovascular disease in diabetic patients
Material and Methods: Study included 60 patients and 30 controls with age 20-45 years. About 30 diabetic
patients with duration of diabetes>five year (Group A) and 30 cases of type 2 diabetics with duration of
diabetes<one year (Group B) were included. Another 30 subjects with no history of any disease were recruited as
controls (Group C). Blood sample of both subjectsand controls was drawn to estimate the levels of serum
malondialdehyde, serum catalase, fasting blood sugar, serum catalase, serum cholesterol and serum triglyceride
using standard kits.
Results: Male/female ratio was 1:2&1:3 in groups A & B respectively. Majority of middle-aged diabetic of both groups were smokers, professional and having moderately active lifestyle. Nearly all patients were non obese with positive family history of diabetes. Mean levels of fasting blood sugar, serum MDA, serum cholesterol was high in Group A compared to Group B and controls. The mean level of serum triglycerides was high in Group B compared to Group A& controls. The levels of serum catalase were low in both A & B compared to group C. According to analysis of variance, significant difference was observed in values of fasting blood sugar, serum MDA, serum catalase, serum cholesterol and triglycerides between groupsA, B & C.
Conclusion: Reduced level of catalase and increased values of malondialdehyde cause imbalance of oxidative stress that may increase the risk of cardiovascular disease in both new and known diabetic patients.