Wilms Tumor Different Histology Patterns Observed in Tertiary Care Hospital

Authors

  • Bushra Nisar Children Hospital Lahore
  • Saadia Sharif The University of Lahore-Pakistan
  • Abeer Zaheer Children Hospital Lahore
  • Samina Zaman Children Hospital Lahore
  • Mehwish Hussain Children Hospital Lahore
  • Zunaira Jamshed Fatima memorial Hospital Lahore
  • Tayyaba Yasin The University of Campania Luigi Vanvitelli, Italy

DOI:

https://doi.org/10.51273/esc24.251320224

Abstract

Objective: The objective of this descriptive study was to investigate the age distribution, gender prevalence,
clinical presentations, histological patterns, tumor staging, and outcomes of WT in a local pediatric population.
Material and Methods: The study conducted over 9 months at Children Hospital, Lahore. The study included
120 patients with WT. Clinical data, age, gender, and staging information were collected. Biopsies were
analyzed for histological patterns, and SPSS version 26 was used for statistical analysis.
Results: The study revealed a mean age of 5.79 years, with a slight male predominance (58.3%). Abdominal
mass was the predominant clinical presentation (47.5%), and the tri-phasic histological pattern, often with blastemal predominance, was most prevalent (52.5%). The majority of cases were diagnosed at Stage-I (59.2%). No significant associations were found between age, gender, and tumor subtypes.
Conclusion: The findings reveal a predominance of the tri-phasic histological pattern with blastemal predominance, aligning with global trends.

Author Biographies

Bushra Nisar, Children Hospital Lahore

Assistant professor Histopathology

Saadia Sharif, The University of Lahore-Pakistan

Associate professor

Abeer Zaheer, Children Hospital Lahore

Assistant professor Histopathology

Samina Zaman, Children Hospital Lahore

Professor Histopathology

Mehwish Hussain, Children Hospital Lahore

Associate professor Histopathology

Zunaira Jamshed, Fatima memorial Hospital Lahore

Medical Student

Tayyaba Yasin, The University of Campania Luigi Vanvitelli, Italy

PhD student

References

van der Kamp A, de Bel T, van Alst L, Rutgers J, van den Heuvel-Eibrink MM, Mavinkurve-Groothuis AM, et al. Automated Deep Learning-Based Classification of Wilms Tumor Histopathology. Cancers. 2023;15(9):2656.

Bánki T, Drost J, van den Heuvel-Eibrink MM, Mavinkurve-Groothuis AM, de Krijger RR. Somatic, Genetic and Epigenetic Changes in Nephrogenic Rests and Their Role in the Transformation to Wilms Tumors, a Systematic Review. Cancers. 2023;15(5):1363.

Soyemi S, Osuoji R, Faduyile F, Sanni D, Oyewole O, Obafunwa J, et al. Morphological Features of Wilms Tumour in a Tertiary Health Care Institution: Our findings. J Clin Exp Pathol. 2013;3(3):1-3.

Spreafico F, Fernandez CV, Brok J, Nakata K, Vujanic G, Geller JI, et al. Wilms tumour. Nature Reviews Disease Primers. 2021;7(1):75.

Loh AH, Radhakrishnan V, Khan MS, Sullivan MJ. Implementation of Multidisciplinary Teams for the Treatment of Childhood Cancer. Pediatric Surgical Oncology: Springer; 2023. p. 1-17.

Das RN, Chatterjee U, Sinha SK, Ray AK, Saha K, Banerjee S. Study of histopathological features and proliferation markers in cases of Wilms′ tumor. Indian Journal of Medical and Paediatric Oncology. 2012;33(02):102-6.

Saltzman AF, Carrasco Jr A, Amini A, Cost NG. Patterns of care and survival comparison of adult and pediatric Wilms tumor in the United States: a study of the National Cancer Database. Urology. 2020;135:50-6.

Pater L, Melchior P, Rübe C, Cooper BT, McAleer MF, Kalapurakal JA, et al. Wilms tumor. Pediatric Blood & Cancer. 2021;68:e28257.

Kakkar D, Mallick S, Ahmad A, Goswami A, Agarwala S, Gupta AK, et al. Differential expression of miRNA in histological subtype of Wilms tumor. Pediatric Surgery International. 2022:1-11.

Mabadeje-Isowo AB, Sowunmi AC, Oyesegun AR, Adenipekun A, Ketiku KK, Okoro US. Management of Wilm's tumor at the Lagos University Teaching Hospital (a 10-year retrospective study). Journal of Clinical Sciences. 2019;16(2):68-73.

Groenendijk A, Spreafico F, de Krijger RR, Drost J, Brok J, Perotti D, et al. Prognostic factors for Wilms tumor recurrence: A review of the literature. Cancers. 2021;13(13):3142.

Cunningham ME, Klug TD, Nuchtern JG, Chintagumpala MM, Venkatramani R, Lubega J, et al. Global disparities in Wilms tumor. Journal of surgical research. 2020;247:34-51.

Popov SD, Sebire NJ, Vujanic GM. Wilms' tumour–histology and differential diagnosis. 2016.

Anwar S, Faizan M, Khan S, Tallat N, Saleem M, Khalid A, et al. Five year experience of Wilms tumor at a tertiary care centre, where we stand, a developing country perspective. 2017.

SHARMA S, Nath P, Srivastava A, Singh K. Wilms' Tumour: A Clinicopathologic Study with Special Reference to its Morphologic Variants. Indian Journal of Pathology and Microbiology. 1995;38(1):55-62.

Leslie SW, Sajjad H, Murphy PB. Wilms tumor. 2017.

Caldwell BT, Wilcox DT, Cost NG. Current management for pediatric urologic oncology. Advances in Pediatrics. 2017;64(1):191-223.

Naseem N, Anwar MA, Nagi AH. Wilms tumor; different histological patterns observed in local children of Pakistan. Rawal Medical Journal. 1970;41(2):197-.

Szychot E, Apps J, Pritchard-Jones K. Wilms’ tumor: biology, diagnosis and treatment. Translational pediatrics. 2014;3(1):12.

Ko EY, Ritchey ML. Current management of Wilms’ tumor in children. Journal of Pediatric Urology. 2009;5(1):56-65.

Marcdante K, Kliegman RM, Jenson H, Behrman R. Essentials of pediatrics. Elsevier, Philadelphia. 2015;11(14):231.

SEER S. Explorer: An interactive website for SEER cancer statistics. Surveillance Research Program, National Cancer Institute. 2021.

Guruprasad B, Rohan B, Kavitha S, Madhumathi D, Lokanath D, Appaji L. Wilms’ tumor: single centre retrospective study from South India. Indian journal of surgical oncology. 2013;4:301-4.

Pushpa B, Duraisamy K. A Study of Histopathological Features in Wilms Tumour in Correlation with Staging. 2019.

Owens CM, Brisse HJ, Olsen ØE, Begent J, Smets AM. Bilateral disease and new trends in Wilms tumour. Pediatric Radiology. 2008;38:30-9.

Downloads

Published

2024-07-18

How to Cite

1.
Bushra Nisar, Saadia Sharif, Abeer Zaheer, Samina Zaman, Mehwish Hussain, Zunaira Jamshed, Yasin T. Wilms Tumor Different Histology Patterns Observed in Tertiary Care Hospital. Esculapio - JSIMS [Internet]. 2024 Jul. 18 [cited 2024 Nov. 21];20(2). Available from: https://esculapio.pk/journal/index.php/journal-files/article/view/1057

Issue

Section

Original Articles