Antioxidant Potential of Cydonia oblonga in Isoproterenol-Induced Myocardial Infarction in rats

Abstract

Objective: An experimental study was carried out to find the antioxidant potential of methanolic leaf extract
of Cydonia oblonga in Isoproterenol-Induced Myocardial Infarction in groups of rats.
Material and Methods: A total of 30 Wistar rats included in the study. Rats were divided into 5 groups
comprising 6 animals per group. Group I was given normal saline while Group II was given normal saline
followed by isoproterenol. Group III, Group IV and Group V received methanolic extract of C. oblonga 50
mg/kg, 100 mg/kg and Carvedilol 2 mg/kg respectively by oral route followed by isoproterenol. Blood
samples were estimated for cardiac biomarkers (Troponin T, CK-MB and LDH). Anti-oxidative stress
biomarkers (catalase, superoxide dismutase, glutathione peroxidase, malanodialdehyde) were also estimated
using cardiac tissue.
Results: C. oblonga at doses of 50 mg/kg & 100 mg/kg significantly reduced the levels of cardiac markers
Troponin T, CK-MB and Lactate dehydrogenase in treatment groups of rats. Significantly high values of anti-
oxidants superoxide dismutase, catalase, and glutathione peroxidase were found only at high dose of extract
of CO. Significantly decreased level of melanodialdehyde was found in treatment groups.
Conclusion: Study revealed that due to antioxidant characteristics, C. oblonga showed cardioprotective
activity against myocardial infarction.